Abstract
Background and Aims
Acute pancreatitis (AP) and chronic pancreatitis (CP) often represent parts of the
spectrum of disease. While growing evidence indicates that intra-pancreatic fat deposition
(IPFD) plays an important role in the pathogenesis of pancreatitis, no study of living
individuals has investigated IPFD in both AP and CP. Further, the associations between
IPFD and gut hormones remain to be elucidated. The aims were to investigate the associations
of IPFD with AP, CP, and health; and to study whether gut hormones affect these associations.
Methods
Magnetic resonance imaging on the same 3.0 Tesla scanner was used to determine IPFD
in 201 study participants. These participants were arranged into the health, AP, and
CP groups. Gut hormones (ghrelin, glucagon-like peptide-1, gastric inhibitory peptide,
peptide YY, and oxyntomodulin) were measured in blood, both after an 8-hour overnight
fasting and after ingestion of a standardised mixed meal. A series of linear regression
analyses was run, accounting for age, sex, ethnicity, body mass index, glycated haemoglobin,
and triglycerides.
Results
Both the AP group and CP group had significantly higher IPFD in comparison with the
health group, consistently across all models (p for trend 0.027 in the most adjusted
model). Ghrelin in the fasted state had a significant positive association with IPFD
in the AP group (but not the CP or health group), consistently across all models (p = 0.019 in the most adjusted model). None of the studied gut hormones in the postprandial
state was significantly associated with IPFD.
Conclusion
Fat deposition in the pancreas is similarly high in individuals with AP and those
with CP. The gut-brain axis, and more specifically overexpression of ghrelin, may
contribute to increased IPFD in individuals with AP.
Keywords
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Article info
Publication history
Published online: March 04, 2023
Accepted:
February 15,
2023
Received:
September 12,
2022
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2023 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
