Abstract
Background
Little is known about the prognosis of colorectal cancer associated with inflammatory
bowel disease (CRC-IBD) in a real-world cohort in France.
Methods
We conducted a retrospective observational study including all patients presenting
CRC-IBD in a French tertiary center.
Results
Among 6510 patients, the rate of CRC was 0.8% with a median delay of 19.5 years after
IBD diagnosis (median age 46 years, ulcerative colitis 59%, initially localized tumor
69%). There was a previous exposure to immunosuppressants (IS) in 57% and anti-TNF
in 29% of the cases. A RAS mutation was observed in only 13% of metastatic patients.
OS of the whole cohort was 45 months. OS and PFS of synchronous metastatic patients
was 20.4 months and 8.5 months respectively. Among the patients with localized tumor
those previously exposed to IS had a better PFS (39 months vs 23 months; p = 0.05) and OS (74 vs 44 months; p = 0.03). The IBD relapse rate was 4%. No unexpected chemotherapy side-effect was
observed
Conclusions
OS of CRC-IBD is poor in metastatic patients although IBD is not associated with under-exposure
or increased toxicity to chemotherapy. Previous IS exposure may be associated with
a better prognosis.
Key words
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Article info
Publication history
Published online: March 04, 2023
Accepted:
February 16,
2023
Received:
November 7,
2022
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2023 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
