Abstract
Background and aims
This work aimed to evaluate the impact of sarcopenia and sarcopenic obesity on the
occurrence of severe pancreatitis and to study the performance of anthropometric indices
to predict severe forms.
Methods
We conducted a single-center retrospective study at Caen University Hospital between
2014 and 2017. Sarcopenia was assessed by measuring the psoas area on an abdominal
scan. The psoas area /body mass index ratio reflected sarcopenic obesity. By normalizing
the value to the body surface, we obtained an index called sarcopancreatic index,
avoiding sex differences in measurements.
Results
Among 467 included patients, 65 (13.9%) developed severe pancreatitis. The sarcopancreatic
index was independently associated with the occurrence of severe pancreatitis (1.455
95% CI [1.028–2.061]; p = 0.035), as was the Visual Analog Scale, creatinine or albumin. The complication
rate was not different depending on sarcopancreatic index value. Based on variables
independently associated with the occurrence of severe pancreatitis, we constructed
a score called Sarcopenia Severity Index. This score presented an area under the receiver
operating characteristics curve of 0.84, comparable to the Ranson score (0.87) and
superior to body mass index or the sarcopancreatic index to predict a severe form
of acute pancreatitis.
Conclusions
Sarcopenic obesity seems to be associated with severe acute pancreatitis.
Keywords
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Article info
Publication history
Published online: February 26, 2023
Accepted:
February 9,
2023
Received:
August 9,
2022
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2023 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
