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The differences in biological behavior and gene expression characteristics between pure and mixed early gastric signet ring cell carcinomas

  • Author Footnotes
    1 The authors should be considered joint first author.
    Xiaoyong Wang
    Footnotes
    1 The authors should be considered joint first author.
    Affiliations
    Department of Gastroenterology, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, 29 Xinglong Lane, Tianning District, Changzhou 213000, China
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  • Author Footnotes
    1 The authors should be considered joint first author.
    Xuan Li
    Footnotes
    1 The authors should be considered joint first author.
    Affiliations
    Department of Gastroenterology, Jiangsu Province Hospital and Nanjing Medical University First Affiliated Hospital, Nanjing 210000, China
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  • Author Footnotes
    1 The authors should be considered joint first author.
    Peng Yang
    Footnotes
    1 The authors should be considered joint first author.
    Affiliations
    Department of Gastroenterology, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, 29 Xinglong Lane, Tianning District, Changzhou 213000, China
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  • Xiangrong Qin
    Affiliations
    Department of Gastroenterology, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, 29 Xinglong Lane, Tianning District, Changzhou 213000, China
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  • Jing Yu
    Affiliations
    Department of Gastroenterology, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, 29 Xinglong Lane, Tianning District, Changzhou 213000, China
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  • Yuqing Cheng
    Affiliations
    Department of Pathology, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou 213000, China
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  • Guoxin Zhang
    Affiliations
    Department of Gastroenterology, Jiangsu Province Hospital and Nanjing Medical University First Affiliated Hospital, Nanjing 210000, China
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  • Liming Tang
    Correspondence
    Corresponding author.
    Affiliations
    Department of General surgery, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou 213000, China
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  • Author Footnotes
    1 The authors should be considered joint first author.
Published:December 16, 2022DOI:https://doi.org/10.1016/j.dld.2022.11.018

      Abstract

      Background

      The biological behavior of signet ring cell carcinoma (SRCC) in early gastric cancer (EGC) is not well understood.

      Aims

      We aimed to investigate the clinicopathologic and prognostic differences, and explore differences in the gene expression characteristics between pure early SRCC and mixed early SRCC.

      Methods

      We retrospectively analyzed 1707 EGC patients. We also conducted a meta-analysis to compare biological behavior in pure SRCC and mixed SRCC. We explored gene expression levels of N6-methyadenosine (m6A) regulators in pure SRCC and mixed SRCC.

      Results

      Compared with pure SRCC, mixed SRCC was associated with an increased risk of submucosal invasion, perineural invasion, LVI and LNM. LNM was more common in mixed SRCC than with pure SRCC who met the indications for endoscopic submucosal dissection (ESD) (16.67% vs 2.78%). There was no difference in the overall survival between pure SRCC and mixed SRCC in EGCs (P=0.10). Expression of m6A regulators WTAP, FTO and VIRMA was significantly higher in mixed SRCC than that in pure SRCC (P<0.05).

      Conclusion

      Mixed SRCC displayed more aggressive biological behavior than pure SRCC in EGC. WTAP, FTO and VIRMA were expressed at significantly different levels in the two types of EGC, and may have important roles in the observed differences in biological behavior.

      Keywords

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