Abstract
Background
The biological behavior of signet ring cell carcinoma (SRCC) in early gastric cancer
(EGC) is not well understood.
Aims
We aimed to investigate the clinicopathologic and prognostic differences, and explore
differences in the gene expression characteristics between pure early SRCC and mixed
early SRCC.
Methods
We retrospectively analyzed 1707 EGC patients. We also conducted a meta-analysis to
compare biological behavior in pure SRCC and mixed SRCC. We explored gene expression
levels of N6-methyadenosine (m6A) regulators in pure SRCC and mixed SRCC.
Results
Compared with pure SRCC, mixed SRCC was associated with an increased risk of submucosal
invasion, perineural invasion, LVI and LNM. LNM was more common in mixed SRCC than
with pure SRCC who met the indications for endoscopic submucosal dissection (ESD)
(16.67% vs 2.78%). There was no difference in the overall survival between pure SRCC
and mixed SRCC in EGCs (P=0.10). Expression of m6A regulators WTAP, FTO and VIRMA was significantly higher
in mixed SRCC than that in pure SRCC (P<0.05).
Conclusion
Mixed SRCC displayed more aggressive biological behavior than pure SRCC in EGC. WTAP,
FTO and VIRMA were expressed at significantly different levels in the two types of
EGC, and may have important roles in the observed differences in biological behavior.
Keywords
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Article info
Publication history
Published online: December 16, 2022
Accepted:
November 16,
2022
Received:
June 11,
2022
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2022 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
