We would like to thank Dr. Zanetto and colleagues for their interest in our work and
for sharing their valuable findings in regard to plasma von Willebrand factor antigen
(VWF:Ag) levels in patients with acute decompensation (AD) and their lack of association
with acute-on-chronic liver failure (ACLF) development and death [
[1]
].To read this article in full you will need to make a payment
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References
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Article info
Publication history
Published online: November 12, 2022
Accepted:
October 24,
2022
Received:
October 18,
2022
Identification
Copyright
© 2022 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
ScienceDirect
Access this article on ScienceDirectLinked Article
- von Willebrand factor in hospitalized patients with acute decompensation of cirrhosis is increased but not associated with development of ACLFDigestive and Liver DiseaseVol. 55Issue 1
- PreviewWe read with interest the original article by Pomej et al, which was recently published in Digestive and Liver Disease [1]. In a large, retrospective cohort of clinically stable patients with cirrhosis, these Authors demonstrated that a “substantially elevated” level of von Willebrand factor antigen (i.e.: >420%) was predictive of hepatic decompensation and liver-related mortality independently of age, etiology of liver disease, Child-Pugh stage, severity of portal hypertension, serum creatine, and C-reactive protein [1].
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- Clinical significance of substantially elevated von Willebrand factor antigen levels in patients with advanced chronic liver diseaseDigestive and Liver DiseaseVol. 54Issue 10
- PreviewVon Willebrand factor antigen (VWF) is a non-invasive marker for clinically significant portal hypertension (HVPG≥10 mmHg) and confers HVPG-independent prognostic information. While quantification of increased VWF-levels is not relevant in the context of von Willebrand disease, highly elevated VWF may be of clinical significance in ACLD. Thus, we have modified our analytical approach to quantify very high VWF-levels (i.e.,>420%) and investigated their prognostic value.
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