Abstract
Background
Cholangiocarcinoma (CCA) is a rare biliary tract tumor with poor prognosis that often
is challenging to diagnose and the majority of patients present with advanced stage.
Squamous cell carcinoma antigen 1 (SCCA1) overexpression has been found in different
tumors associated with poor prognosis and chemoresistance.
Aims
To assess the presence and possible prognostic role of SCCA1/2 isoforms in bile and
serum of patients with CCA.
Methods
Forty seven surgical patients (36 with CCA and 11 with benign diseases) were prospectively
included in the study. Serum and bile specimens were collected at the time of surgery
and free and IgM-complexed SCCA was quantified by ELISA (Xeptagen, srl).
Results
Free or IgM linked SCCA was rarely found in serum, while SCCA was detectable in bile
samples of patients with CCA, especially in those with extrahepatic form (43% vs 17%,
p = 0.008), but not in controls. Despite similar tumor stage, these positive patients
presented a trend toward a higher percentage of portal invasion (27% vs 15%) and of
tumor recurrence than negative cases (62% vs 40%), although the difference was not
statistically significant.
Conclusion
These preliminary results indicate that bile testing for SCCA is a specific marker
of extrahepatic CCA, with potential prognostic value.
Keywords
Abbreviations:
CCA (Cholangiocarcinoma), i-CCA (intrahepatic cholangiocarcinoma), e-CCA (extrahepatic cholangiocarcinoma), d-CCA (distal cholangiocarcinoma), p-CCA (perihilar cholangiocarcinoma)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: November 08, 2022
Accepted:
October 13,
2022
Received:
January 22,
2022
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2022 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
