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von Willebrand factor in hospitalized patients with acute decompensation of cirrhosis is increased but not associated with development of ACLF

  • Alberto Zanetto
    Correspondence
    Corresponding author at: Dr. Alberto Zanetto, MD, PhD, Gastroenterology and Multivisceral Transplant Unit, Department of Surgery, Oncology, and Gastroenterology, Padua University Hospital, Padua, Italy.
    Affiliations
    Gastroenterology and Multivisceral Transplant Unit, Azienda Ospedale - Università Padova, Padova, Italy

    Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy
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  • Elena Campello
    Affiliations
    General Internal Medicine and Thrombotic and Hemorrhagic Diseases Unit, Department of Medicine, Padova University Hospital, Padova, Italy
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  • Cristiana Bulato
    Affiliations
    General Internal Medicine and Thrombotic and Hemorrhagic Diseases Unit, Department of Medicine, Padova University Hospital, Padova, Italy
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  • Patrizia Burra
    Affiliations
    Gastroenterology and Multivisceral Transplant Unit, Azienda Ospedale - Università Padova, Padova, Italy

    Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy
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  • Marco Senzolo
    Affiliations
    Gastroenterology and Multivisceral Transplant Unit, Azienda Ospedale - Università Padova, Padova, Italy

    Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy
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  • Paolo Simioni
    Affiliations
    General Internal Medicine and Thrombotic and Hemorrhagic Diseases Unit, Department of Medicine, Padova University Hospital, Padova, Italy
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Published:October 22, 2022DOI:https://doi.org/10.1016/j.dld.2022.10.001
      We read with interest the original article by Pomej et al, which was recently published in Digestive and Liver Disease [
      • Pomej K
      • Scheiner B
      • Balcar L
      • Nussbaumer RJ
      • Weinzierl J
      • Paternostro R
      • et al.
      Clinical significance of substantially elevated von Willebrand factor antigen levels in patients with advanced chronic liver disease.
      ]. In a large, retrospective cohort of clinically stable patients with cirrhosis, these Authors demonstrated that a “substantially elevated” level of von Willebrand factor antigen (i.e.: >420%) was predictive of hepatic decompensation and liver-related mortality independently of age, etiology of liver disease, Child-Pugh stage, severity of portal hypertension, serum creatine, and C-reactive protein [
      • Pomej K
      • Scheiner B
      • Balcar L
      • Nussbaumer RJ
      • Weinzierl J
      • Paternostro R
      • et al.
      Clinical significance of substantially elevated von Willebrand factor antigen levels in patients with advanced chronic liver disease.
      ].

      Keywords

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