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Colectomy rates for ulcerative colitis over time: Navigating the evidence in the era of precision medicine and individualised treatment

  • Gianluca Pellino
    Correspondence
    Corresponding author at: Department of Advanced Medical and Surgical Sciences, Università degli Studi della Campania “Luigi Vanvitelli”, Naples, Italy.
    Affiliations
    Department of Advanced Medical and Surgical Sciences, Università degli Studi della Campania “Luigi Vanvitelli, Naples, Italy

    Colorectal Surgery, Vall d'Hebron University Hospital, Barcelona, Spain
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  • Alessandro Armuzzi
    Correspondence
    Corresponding author at: IBD Center, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy and Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
    Affiliations
    IBD Center, IRCCS Humanitas Research Hospital, Milan, Rozzano, Italy

    Department of Biomedical Sciences, Humanitas University, Milan, Pieve Emanuele, Italy
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Published:October 27, 2022DOI:https://doi.org/10.1016/j.dld.2022.09.017
      Nick Dai and colleagues [
      • Dai N.
      • Haidar O.
      • Askari A.
      • Segal J.
      Colectomy rates in Ulcerative colitis: a systematic review and meta-analysis.
      ] conducted an up-to-date review of the literature to assess the rates of colectomy for ulcerative colitis (UC) over time, also comparing the pre-biologic vs biologic drug eras. Indeed many clinicians and their patients hoped that biologics would reduce, or even eliminate, the need for surgery,1 and whilst a reduction in colectomy rates occurred, the effect is smaller than expected.
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