Abstract
Background and aims
Alteration of platelet status associates with decompensation and death in cirrhosis,
while its effect on portal vein thrombosis (PVT) remains unclear. We aimed to retrospectively
investigate whether PVT associates with platelet-fibrin clot strength and platelet
activation in decompensated cirrhosis.
Methods
Platelet-fibrin clot strength (G) was measured by thromboelastography (TEG). Platelet
activation was reflected by plasma concentrations of soluble p-selectin (sPs) and
a platelet aggregation test adjusted for platelet counts.
Results
Among 166 patients, 45 had PVT. The platelet count was significantly lower in PVT.
While the G value was positively correlated with platelet count (ρ = 0.74, P < 0.01), increased G was associated with PVT after adjusting for platelet count in
the logistic regression (P = 0.04). The normalized G value according to the linear relation with platelet count
was calculated as follows: Gplatelet = [(G - 2622)/platelet count]. This coefficient had no correlation with platelet
count and was an independent risk factor of PVT (OR = 1.03, CI95%: 1.01-1.05, P = 0.012). In two subanalyses, the collagen-induced platelet aggregation (n = 37,
P = 0.029) and plasma concentration of sPs (n = 56, P = 0.001) adjusted for platelet count were significantly higher in PVT.
Conclusion
This study showed a positive correlation of high platelet-fibrin clot strength detected
via TEG and platelet activation with PVT in decompensated cirrhosis.
Keywords
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Article info
Publication history
Published online: October 21, 2022
Accepted:
September 30,
2022
Received:
May 16,
2022
Publication stage
In Press Corrected ProofFootnotes
Grant support: This study was supported by the Sichuan Science and Technology Program (Grant No. 22ZDYF0621), 1·3·5 project for disciplines of excellence – Clinical Research Incubation Project (2019HXFH024), West China Hospital, Sichuan University, Technological innovation R&D project of Chengdu Science and Technology Bureau (2021-YF05-01285-SN), National Natural Science Foundation of China (Grant No. 82270649) and Sichuan Science and Technology Program (2020YFS0236).
Conflict of Interest: The authors have no conflicts of interest to disclose.
Identification
Copyright
© 2022 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
