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Commentary| Volume 54, ISSUE 12, P1662-1663, December 2022

Waiting list trends for liver transplantation in Italy: A snapshot from the future

  • Alessio Aghemo
    Affiliations
    Division of Internal Medicine and Hepatology, Department of Gastroenterology, IRCCS Humanitas Research Hospital, Rozzano, Italy

    Department of Biomedical Sciences, Humanitas University, Pieve Emanuele (MI), Italy
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  • Quirino Lai
    Correspondence
    Corresponding author at: General Surgery and Organ Transplantation Unit, Department of General and Specialistic Surgery, Sapienza University of Rome, AOU Policlinico Umberto I of Rome, Viale del Policlinico 155, 00161 Rome, Italy.
    Affiliations
    General Surgery and Organ Transplantation Unit, AOU Policlinico Umberto I, Sapienza University of Rome, Italy
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Published:October 12, 2022DOI:https://doi.org/10.1016/j.dld.2022.09.013
Waiting list trends for liver transplantation in Italy: A snapshot from the future
Previous ArticleMesenteric panniculitis is associated with cardiovascular risk-factors: A case-control study
Next ArticleTemporal trends of waitlistings for liver transplantation in Italy: The ECALITA (Evolution of IndiCAtion in LIver transplantation in ITAly) registry study
      In recent years, significant changes have been observed in the field of liver transplantation (LT). On one side, the introduction of direct-acting antivirals (DAA) has modified the impact of HCV, mainly in areas like Italy, where the virus was endemic [
      • Menini F.S.
      • Marcellusi A.
      • Robbins Scott S.
      • et al.
      The impact of direct acting antiviral on Hepatitis C virus disease burden and associated cots in four European countries.
      Liver Int. 2021; 41: 934-948
      ]. On the other side, a growing number of patients with metabolic dysfunction-associated fatty liver disease (MAFLD) has been reported, mainly in countries with a high prevalence of obesity [
      • Cholankeril G.
      • Wong R.J.
      • Hu M.
      • et al.
      Liver transplantation for nonalcoholic steatohepatitis in the US: temporal trends and outcomes.
      Dig Dis Sci. 2017; 62: 2915-2922
      ]. Nevertheless, Italy is also experiencing an increase in this pathology [
      • Vitale A.
      • Svegliati-Baroni G.
      • Ortolani A.
      • et al.
      Epidemiological trends and trajectories of MAFLD-associated hepatocellular carcinoma 2002-2033: the ITA.LI.CA database.
      Gut. 2021 Dec 21; (gutjnl-2021-324915)
      ].

      Keywords

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      References

        • Menini F.S.
        • Marcellusi A.
        • Robbins Scott S.
        • et al.
        The impact of direct acting antiviral on Hepatitis C virus disease burden and associated cots in four European countries.
        Liver Int. 2021; 41: 934-948
        View in Article
        • Cholankeril G.
        • Wong R.J.
        • Hu M.
        • et al.
        Liver transplantation for nonalcoholic steatohepatitis in the US: temporal trends and outcomes.
        Dig Dis Sci. 2017; 62: 2915-2922
        View in Article
        • Vitale A.
        • Svegliati-Baroni G.
        • Ortolani A.
        • et al.
        Epidemiological trends and trajectories of MAFLD-associated hepatocellular carcinoma 2002-2033: the ITA.LI.CA database.
        Gut. 2021 Dec 21; (gutjnl-2021-324915)
        View in Article
        • Younossi Z.
        • Stepanova M.
        • Ong J.P.
        • et al.
        Nonalcoholic steatohepatitis is the fastest growing cause of hepatocellular carcinoma in liver transplant candidates.
        Clin Gastroenterol Hepatol. 2019; 17 (.e3): 748-755
        View in Article
        • Sapisochin G.
        • Hibi T.
        • Toso C.
        • et al.
        Transplant oncology in primary and metastatic liver tumors: principles, evidence, and opportunities.
        Ann Surg. 2021; 273: 483-493
        View in Article
        • Manzia T.M.
        • Trapani S.
        • Nardi A.
        • et al.
        Temporal trends of waitlistings for liver transplantation in Italy: the ECALITA (Evolution of IndiCAtion in LIver Transplantation in ITAly) Registry Study.
        Dig Liver Dis. 2022; 54: 1664-1671
        View in Article
        • Belli L.S.
        • Berenguer M.
        • Cortesi P.A.
        • et al.
        Delisting of liver transplant candidates with chronic hepatitis C after viral eradication: a European study.
        J Hepatol. 2016; 65: 524-531
        View in Article
        • Arora S.S.
        • Axley P.
        • Ahmed Z.
        • Satapathy S.K.
        • Wong R.
        • Kuo Y.F.
        • Singal A.K.
        Decreasing frequency and improved outcomes of hepatitis C-related liver transplantation in the era of direct-acting antivirals - a retrospective cohort study.
        Transpl Int. 2019; 32: 854-864
        View in Article
        • Fei Ye F.
        • Zhai M.
        • Long J.
        • et al.
        The burden of liver cirrhosis in mortality: results from the global burden of disease study.
        Front Public Health. 2022; 10909455
        View in Article
        • Park C.W.
        • Tsai N.T.
        • Wong L.L.
        Implications of worse renal dysfunction and medical comorbidities in patients with NASH undergoing liver transplant evaluation: impact on MELD and more.
        Clin Transplant. 2011; 25: E606-E611
        View in Article
        • Yang J.D.
        • Larson J.J.
        • Watt K.D.
        • Allen A.M.
        • Wiesner R.H.
        • Gores G.J.
        • Roberts L.R.
        • Heimbach J.A.
        • Leise M.D.
        Hepatocellular carcinoma is the most common indication for liver transplantation and placement on the waitlist in the United States.
        Clin Gastroenterol Hepatol. 2017; 15 (.e3): 767-775
        View in Article
        • Guarino M.
        • Viganò L.
        • Ponziani F.R.
        • et al.
        Recurrence of hepatocellular carcinoma after direct acting antiviral treatment for hepatitis C virus infection: literature review and risk analysis.
        Dig Liver Dis. 2018; 50: 1105-1114
        View in Article
        • Lerut J.
        • Foguenne M.
        • Lai Q.
        Hepatocellular cancer selection systems and liver transplantation: from the tower of babel to an ideal comprehensive score.
        Updates Surg. 2021; 73: 1599-1614
        View in Article
        • Solheim J.M.
        • Dueland S.
        • Line P.D.
        • Hagness M.
        Transplantation for nonresectable colorectal liver metastases - long term follow- up of the first prospective pilot study.
        Ann Surg. 2022 Sep 9; https://doi.org/10.1097/SLA.0000000000005703
        View in Article
        • Ravaioli M.
        • Lai Q.
        • Sessa M.
        • et al.
        Impact of MELD 30-allocation policy on liver transplant outcomes in Italy.
        J Hepatol. 2022; 76: 619-627
        View in Article

      Article info

      Publication history

      Published online: October 12, 2022
      Accepted: September 29, 2022
      Received: September 26, 2022

      Footnotes

      Supported by: The authors have not received any support for the present study.

      Identification

      DOI: https://doi.org/10.1016/j.dld.2022.09.013

      Copyright

      © 2022 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

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