If you don't remember your password, you can reset it by entering your email address and clicking the Reset Password button. You will then receive an email that contains a secure link for resetting your password
If the address matches a valid account an email will be sent to __email__ with instructions for resetting your password
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, JapanDepartment of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
A 73-year-old woman visited our institution because of tumor regurgitation. Barium
esophagography revealed the long pedunculated lesion in the esophagus (Fig. 1a). Esophagogastroduodenoscopy (EGD) showed the lesion covered with normal mucosa
(Fig. 1b). The lesion arose from the hypopharynx, and was completely dissociated from the
esophagus. Because she was symptomatic, endoscopic submucosal dissection (ESD) with
the use of esophagogastroduodenoscope and the needle- and scissors-type knives was
performed under general anesthesia and the insertion of a curved rigid laryngoscope.
Macroscopically, the resected mass, measuring 105 × 15 mm in size, consisted of a
soft polypoid lesion (Fig. 1c). Microscopically, there were 2 components (Fig. 2a): one area with spindle- to polygonal-shaped tumor cells (Fig. 2b) and the other area with adipocytes and atypical lipoblasts (Fig. 2c). Immunohistochemically, the tumor cells were positive for MDM2, CDK4 and p16. MDM2 gene amplification was detected by fluorescence in situ hybridization (Fig. 2d). The histopathological diagnosis was hypopharyngeal dedifferentiated liposarcoma
(DDLS) with well-differentiated liposarcoma component. 18F-fluorodeoxyglucose positron emission tomography and EGD performed six months later
showed neither remnant nor metachronous tumor.
Fig. 1(a) Barium esophagography reveals the long pedunculated lesion with the smooth surface
in the esophagus. (b) Esophagogastroduodenoscopy shows the long pedunculated lesion
covered with normal mucosa extending from the hypopharynx to the middle thoracic esophagus.
(c) Macroscopically, the mass resected by endoscopic submucosal dissection, measuring
105 × 15 mm in size, consists of a soft polypoid lesion with the smooth surface.
Fig. 2(a) Histological examination of the resected specimen. The tumor is comprised of two
components. (b) High-power view of the white box in Fig. 2a shows spindle- to polygonal-shaped tumor cells with enlarged, hyperchromatic and
irregular-shaped nuclei. (c) High-power view of the black box in Fig. 2a shows various-sized adipocytes and atypical lipoblasts. (d) MDM2 gene amplification is detected by fluorescence in situ hybridization.
Polypoid fibroadipose tumors of the esophagus: 'giant fibrovascular polyp' or liposarcoma? A clinicopathological and molecular cytogenetic study of 13 cases.
