Abstract
Pancreatic adenocarcinoma (PA) incidence is rising worldwide, especially in France.
The evolution of known risk factors such as tobacco smoking, obesity, type 2 diabetes,
chronic pancreatitis, or constitutional mutations is not sufficient to explain this
trend. Pesticides are known risk factors in other malignancies. Previous studies have
outlined pesticides' influence in PA, such as dichlorodiphenyltrichloroethane as plausible
risk factors. The general population is directly or indirectly exposed to pesticides
through air, food or water. Some of these chemicals may accumulate in the body all
along lifetime and may harm carriers. The toxic mixing effects of these chemicals
are not well documented. Several hypotheses have been put forward to explain how pesticides
can induce indirect (fatty pancreas, induced diabetes) or direct (oxidative stress,
cell damage) carcinogenesis in pancreatic cells through inflammation. A strong corpus
exists acknowledging pesticides as a PA risk factor. However, published studies do
not provide a sufficient level of evidence to prove causality and current prospective
case-control studies are still ongoing.
Keywords
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Article info
Publication history
Published online: September 08, 2022
Accepted:
August 17,
2022
Received:
April 26,
2022
Identification
Copyright
© 2022 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
