Abstract
Background
Few studies focused on minor adverse events which may develop after colonoscopy.
Aims
To investigate the incidence and factors associated to post-colonoscopy symptoms.
Methods
This is a prospective study conducted in 10 Italian hospitals. The main outcome was
a cumulative score combining 10 gastrointestinal (GI) symptoms occurring the week
following colonoscopy. The analyses were conducted via multivariate logistic regression.
Results
Of 793 subjects included in the analysis, 361 (45.5%) complained the new onset of
at least one GI symptom after the exam; one symptom was reported by 202 (25.5%), two
or more symptoms by 159 (20.1%). Newly developed symptoms more frequently reported
were epigastric/abdominal bloating (32.2%), pain (17.3%), and dyspeptic symptoms (17.9%).
Symptoms were associated with female sex (odds ratio [OR]=2.54), increasing number
of symptoms developed during bowel preparation intake (OR=1.35) and somatic symptoms
(OR=1.27). An inverse association was observed with better mood (OR=0.74). A high-risk
profile was identified, represented by women with bad mood and somatic symptoms (OR=8.81).
Conclusion
About half of the patients develop de novo GI symptoms following colonoscopy. Improving bowel preparation tolerability may reduce
the incidence of post-colonoscopy symptoms, especially in more vulnerable patients.
Keywords
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References
- Quality indicators for colonoscopy.Am J Gastroenterol. Jan 2015; 110: 72-90
- Anxiety associated with colonoscopy and flexible sigmoidoscopy: a systematic review.Am J Gastroenterol. Dec 2018; 113: 1810-1818
- Post-colonoscopy complications: a systematic review, time trends, and meta-analysis of population-based studies.Am J Gastroenterol. Aug 2016; 111: 1092-1101
- Impact of colonoscopy on working productivity: a prospective multicenter observational study.Gastrointest Endosc. 2021 Dec 8; (S0016-5107(21)01868-X)
Collatuzzo G., Fuccio L., Radaelli F. et al. Symptoms related to bowel preparation for colonoscopy: identification of associated factors and high-risk subjects in a working population (submitted to DLD).
- Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome.Gastroenterology. 2004; 126: 693-702
- Nerve fiber outgrowth is increased in the intestinal mucosa of patients with irritable bowel syndrome.Gastroenterology. 2015; 148: 1002-1011
- The Brief Symptom Inventory: an introduction report.Psychol Med. 1983; 13: 595-605
- The Italian SF-36 Health Survey: translation, validation and norming.J Clin Epidemiol. 1998; 51: 1025-1036
- Development and validation of the Mayo Clinic Bowel Prep Tolerability Questionnaire.Dig Liver Dis. 2014; 46: 808-812
- When and how should multiple imputation be used for handling missing data in randomised clinical trials—A practical guide with flowcharts.BMC Med. Res. Methodol. 2017; 17: 162
- Gut microbiota, dysbiosis and colon lavage.Dig Liver Dis. Sep 2019; 51: 1209-1213
- Effects of bowel cleansing on the intestinal microbiota.Gut. Oct 2015; 64 (Epub 2014 Dec 19. PMID: 25527456): 1562-1568https://doi.org/10.1136/gutjnl-2014-307240
- Randomized controlled trial of probiotic use for post-colonoscopy symptoms.ANZ J Surg. 2018; 88: 1-5
- Clinical Services Committee of The British Society of Gastroenterology. Guidelines on the irritable bowel syndrome: mechanisms and practical management.Gut. Dec 2007; 56: 1770-1798
- Functional abdominal pain: further evidence that whole gut is affected.Br Med J (Clin Res Ed). Jun 5 1982; 284: 1670-1672
- Colon distention induces persistent visceral hypersensitivity by mechano transcription of pain mediators in colonic smooth muscle cells.Am J Physiol Gastrointest Liver Physiol. Mar 1 2015; 308: G434-G441
- The incidence of 30-day adverse events after colonoscopy among outpatients in the Netherlands.Am J Gastroenterol. Jun 2012; 107: 878-884
- Prospective analysis of complications 30 days after outpatient colonoscopy.Gastrointest Endosc. 1999; 50: 322-328
- Incidence of minor complications and time lost from normal activities after screening or surveillance colonoscopy.Gastrointest Endosc. 2007; 65: 648-656
Article info
Publication history
Published online: September 22, 2022
Accepted:
August 12,
2022
Received:
March 1,
2022
Footnotes
✰In case of two affiliations, the first one refers where the study was performed.
Identification
Copyright
© 2022 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
