Abstract
Background
Recent studies have shown that IgG4 is increased in the esophageal tissue of eosinophilic
esophagitis patients, including the presence of IgG4+ plasma cells.
Aims
Our aim was to determine whether IgG4 is elevated in the gastric or duodenal tissue
of pediatric patients with eosinophilic gastritis or duodenitis (EoG or EoD).
Methods
This was a retrospective single center study. Pediatric patients were characterized
as having active EoG, EoD, or as controls based on clinical symptoms and histologic
features. Immunohistochemistry for IgG4 was performed in gastric and duodenal tissue,
and peak IgG4+ cells were compared between groups and after treatment.
Results
The frequency of IgG4+ cells was significantly higher in patients with EoG and EoD
compared to controls in the stomach [EoG 6.5 cells/hpf (3.6-10.9), control 0 cells/hpf
(0-0.7), p<0.0001] and duodenum [EoD 7.5 cells/hpf (2.8-37), control 0.5 cells/hpf
(0.3-1.3), p<0.001)] respectively, and positively correlated with eosinophil counts
(stomach: r 0.74, p<0.0001; duodenum: r 0.57, p<0.0001). The amount of tissue IgG4
was significantly decreased in patients in remission but not in persistently active
disease.
Conclusions
These data suggest local tissue production of IgG4 may be a universal feature of eosinophilic
gastrointestinal disease that tracks with disease activity.
Key words
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Article info
Publication history
Published online: September 02, 2022
Accepted:
August 14,
2022
Received:
June 24,
2022
Footnotes
University of Colorado School of Medicine, 13001 E 17th Pl, Aurora, CO 80045
Sources of Support: T32DK067009 - LAQ, K23DK109263-05 - CMK, R01AI121186 - LAS
Identification
Copyright
© 2022 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
