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BRG1 in cancer: An insufficiently explored and controversial research area

Published:August 21, 2022DOI:https://doi.org/10.1016/j.dld.2022.08.019
      Recently, an interesting study entitled “BRG1 regulates lipid metabolism in hepatocellular carcinoma through the PIK3AP1/PI3K/AKT pathway by mediating GLMP expression” was published in Digestive and Liver Disease [
      • Liu G.
      • Sun B.Y.
      • Sun J.
      • et al.
      BRG1 regulates lipid metabolism in hepatocellular carcinoma through the PIK3AP1/PI3K/AKT pathway by mediating GLMP expression.
      ]. In this study, the authors revealed that Brahma-related gene 1 (BRG1) is significantly elevated in hepatocellular carcinoma (HCC). They further showed that BRG1 promoted lipid droplet deposition in HCC cells by downregulating GLMP and inhibiting the PIK3AP1/PI3K/AKT pathway, whereas downregulating BRG1 decreased lipid droplet deposition in HCC cells. Their results established and clarified that BRG1 is involved in lipid metabolism dysfunction, suggesting BRG1 might serve as therapeutic target for treatment nonalcoholic fatty liver disease-associated HCC. Interestingly, a study performed by Li et al. [
      • Li H.
      • Lan J.
      • Han C.
      • et al.
      Brg1 promotes liver fibrosis via activation of hepatic stellate cells.
      ] showed that BRG1 promotes liver fibrosis by activating hepatic stellate cells and BRG1 deficiency attenuates liver fibrosis in HCC patients. These results indicated that BRG1 down-regulation or inhibition may be a candidate therapy for HCC in future. However, some potential concerns need to be carefully considered.
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      References

        • Liu G.
        • Sun B.Y.
        • Sun J.
        • et al.
        BRG1 regulates lipid metabolism in hepatocellular carcinoma through the PIK3AP1/PI3K/AKT pathway by mediating GLMP expression.
        Dig Liver Dis. 2022; 54: 692-700
        • Li H.
        • Lan J.
        • Han C.
        • et al.
        Brg1 promotes liver fibrosis via activation of hepatic stellate cells.
        Exp Cell Res. 2018; 364: 191-197
        • Wang P.
        • Song X.
        • Cao D.
        • et al.
        Oncogene-dependent function of BRG1 in hepatocarcinogenesis.
        Cell Death Dis. 2020; 11: 91
        • Glaros S.
        • Cirrincione G.M.
        • Palanca A.
        • Metzger D.
        • Reisman D.
        Targeted knockout of BRG1 potentiates lung cancer development.
        Cancer Res. 2008; 68: 3689-3696
        • Zhou Z.
        • Su Y.
        • Fa X.
        Restoration of BRG1 inhibits proliferation and metastasis of lung cancer by regulating tumor suppressor miR-148b.
        Onco Targets Ther. 2015; 8: 3603-3612

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