Recently, an interesting study entitled “BRG1 regulates lipid metabolism in hepatocellular
carcinoma through the PIK3AP1/PI3K/AKT pathway by mediating GLMP expression” was published
in Digestive and Liver Disease [
[1]
]. In this study, the authors revealed that Brahma-related gene 1 (BRG1) is significantly
elevated in hepatocellular carcinoma (HCC). They further showed that BRG1 promoted
lipid droplet deposition in HCC cells by downregulating GLMP and inhibiting the PIK3AP1/PI3K/AKT
pathway, whereas downregulating BRG1 decreased lipid droplet deposition in HCC cells.
Their results established and clarified that BRG1 is involved in lipid metabolism
dysfunction, suggesting BRG1 might serve as therapeutic target for treatment nonalcoholic
fatty liver disease-associated HCC. Interestingly, a study performed by Li et al.
[
[2]
] showed that BRG1 promotes liver fibrosis by activating hepatic stellate cells and
BRG1 deficiency attenuates liver fibrosis in HCC patients. These results indicated
that BRG1 down-regulation or inhibition may be a candidate therapy for HCC in future.
However, some potential concerns need to be carefully considered.To read this article in full you will need to make a payment
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References
- BRG1 regulates lipid metabolism in hepatocellular carcinoma through the PIK3AP1/PI3K/AKT pathway by mediating GLMP expression.Dig Liver Dis. 2022; 54: 692-700
- Brg1 promotes liver fibrosis via activation of hepatic stellate cells.Exp Cell Res. 2018; 364: 191-197
- Oncogene-dependent function of BRG1 in hepatocarcinogenesis.Cell Death Dis. 2020; 11: 91
- Targeted knockout of BRG1 potentiates lung cancer development.Cancer Res. 2008; 68: 3689-3696
- Restoration of BRG1 inhibits proliferation and metastasis of lung cancer by regulating tumor suppressor miR-148b.Onco Targets Ther. 2015; 8: 3603-3612
Article info
Publication history
Published online: August 21, 2022
Accepted:
August 8,
2022
Received:
August 2,
2022
Identification
Copyright
© 2022 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
ScienceDirect
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- BRG1 regulates lipid metabolism in hepatocellular carcinoma through the PIK3AP1/PI3K/AKT pathway by mediating GLMP expressionDigestive and Liver DiseaseVol. 54Issue 5
