Abstract
Long-term colitis in people with inflammatory bowel disease (IBD) may lead to colon
cancer called colitis-associated colorectal cancer (CAC). Since the advent of preclinical
prototypes of CAC, various immunological messaging cascades have been identified as
implicated in developing this disease. The toll-like receptor (TLR)s, Janus kinase
(JAK)-signal transducer and activator of transcription (STAT), Nuclear factor-kappa
B (NF-κB), mammalian target of rapamycin complex (mTOR), autophagy, and oxidative
stress are only a few of the molecular mechanisms that have been recognized as major
components to CAC progression. These pathways may also represent attractive medicinal
candidates for the prevention and management of CAC. CAC signaling mechanisms at the
molecular level and how their dysregulation may cause illness are summarized in this
comprehensive overview.
Keywords
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Article info
Publication history
Published online: August 21, 2022
Accepted:
August 3,
2022
Received:
February 24,
2022
Identification
Copyright
© 2022 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
