Abstract
Background
Several studies have demonstrated an association between multiple gene hypermethylation
and gastric cancer. However, the intrinsic mechanisms remain elusive and highly debatable.
To this end, our study aims to investigate the correlation between the methylation
status of multiple gene promoters and gastric cancer.
Methods
PubMed, EMBASE, CNKI, WanFang, Cqvip, and Cochrane Library were queried from inception
to May 2021, and the relationship between the methylation status of the CpG islands
and gastric cancer risk was systematically assessed under the inclusion and exclusion
criteria. The incidence of DNA methylation between tumor and non-tumor tissues was
compared, and the clinicopathological significance of DNA methylation in gastric carcinoma
was further evaluated. The odds ratio (OR) was estimated with a 95% confidence interval
(CI), and forest plots were generated using the fixed-effects or random-effects model.
Results
In total, 201 studies were enrolled, and a higher frequency of CpG islands methylation
was identified in gastric cancer tissues than in non-neoplastic tissues. This suggests
that aberrant polygene methylation might be associated with the initial onset and
progression of gastric cancer.
Conclusion
This study sheds light on the significance of polygene methylation status in gastric
cancer. The DNA methylation of these genes may serve as underlying epigenetic biomarkers,
providing a promising molecular diagnostic approach for human gastric cancer clinical
diagnosis. More large randomized trials are needed to confirm the findings.
Keywords
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Article info
Publication history
Published online: April 18, 2022
Accepted:
March 16,
2022
Received:
August 26,
2021
Identification
Copyright
© 2022 Published by Elsevier Ltd on behalf of Editrice Gastroenterologica Italiana S.r.l.
