Abstract
Background
Excessive fat accumulation in adipose tissue depots and organs such as the pancreas
and the liver is associated with systemic low-grade chronic inflammation.
Aims
To investigate the association between abdominal, hepatic, and pancreatic fat and
the circulating level of inflammatory biomarkers.
Methods
We used data from a subsample of the Study of Health in Pomerania (SHIP-Trend, n = 469). The plasma concentration of 37 inflammatory biomarkers was measured using
the Bio-Plex-Pro™-Human-Inflammation-Panel-1. Subcutaneous and visceral adipose tissue
(SAT and VAT), as well as hepatic and pancreatic fat, were determined by magnetic
resonance imaging. We assessed the associations between fat content and inflammatory
biomarkers using multiple linear regression.
Results
Hepatic fat was associated with MMP-2 (β -0.11), PTX3 (β -0.14), and TNFSF12 (β -0.06).
Pancreatic fat was associated with sTNFR1 (β 0.15), sTNFR2 (β 0.11), and sCD163 (β
0.13). VAT and SAT were associated with sCD163 (βVAT 0.20, βSAT 0.16), MMP-2 (βVAT -0.12, βSAT -0.10), OSTCN (βVAT -0.16, βSAT -0.10), sTNFR1 (βVAT 0.13, βSAT 0.13), sTNFR2 (βVAT 0.13, βSA 0.12), TNFSF12 (βVAT -0.11, βSAT -0.08), and TNFSF14 (βVAT 0.21, βSAT 0.20). VAT was additionally associated with TNFSF13B (β 0.08) and CHI3L1 (β 0.07).
Conclusions
Our findings provide new insights into the involvement of hepatic and pancreatic fat
on systemic inflammation.
Keywords
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Article info
Publication history
Published online: February 26, 2022
Accepted:
February 1,
2022
Received:
November 8,
2021
Identification
Copyright
© 2022 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
