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Genomic and metabolomic profiles and their correlations with preclinical signs of endothelial dysfunction measured by Peripheral Arterial Tonometry in Non Alcoholic Fatty Liver Disease

  • M. Masarone
    Affiliations
    Internal Medicine and Hepatology Division, Department of Medicine, Surgery and Odontostomatology ``Scuola Medica Salernitana'', University of Salerno, Baronissi Salerno, Italy
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  • J. Troisi
    Affiliations
    Theoreo srl, Via degli Ulivi 3, 84090, Montecorvino Pugliano, SA, Italy

    Department of Chemistry and Biology “A. Zambelli”, University of Salerno, Baronissi Salerno Italy
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  • B. Motta
    Affiliations
    Internal Medicine and Hepatology Division, Department of Medicine, Surgery and Odontostomatology ``Scuola Medica Salernitana'', University of Salerno, Baronissi Salerno, Italy
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  • M. Lombardi
    Affiliations
    Theoreo srl, Via degli Ulivi 3, 84090, Montecorvino Pugliano, SA, Italy

    Department of Chemistry and Biology “A. Zambelli”, University of Salerno, Baronissi Salerno Italy
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  • P. Torre
    Affiliations
    Internal Medicine and Hepatology Division, Department of Medicine, Surgery and Odontostomatology ``Scuola Medica Salernitana'', University of Salerno, Baronissi Salerno, Italy
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  • R. Sciorio
    Affiliations
    Internal Medicine and Hepatology Division, Department of Medicine, Surgery and Odontostomatology ``Scuola Medica Salernitana'', University of Salerno, Baronissi Salerno, Italy
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  • M. Aquino
    Affiliations
    Internal Medicine and Hepatology Division, Department of Medicine, Surgery and Odontostomatology ``Scuola Medica Salernitana'', University of Salerno, Baronissi Salerno, Italy
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  • M. Persico
    Affiliations
    Internal Medicine and Hepatology Division, Department of Medicine, Surgery and Odontostomatology ``Scuola Medica Salernitana'', University of Salerno, Baronissi Salerno, Italy
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      Background and Aims: NAFLD is associated with insulin resistance, metabolic syndrome (MS) and diabetes and it is an independent CVD risk factor. Endothelial Dysfunction (ED) plays a central role in the pathogenesis of CVD. Preclinical ED can be detected by vascular reactivity studies, such as Peripheral Arterial Tonometry (PAT). Genome Wide Studies (GWAS) identified Single Nucleotide Polymorphisms (SNPs) associated to NAFLD progression. Some of them (ie TM6SF2) have been postulated to influence CVD risk. The use of specific biomarkers related to ED presence in NAFLD may allow an early identification of CVD risk and provide crucial insights into its pathophysiology. This could be addressed through untargeted metabolomics and genomic approaches. Aims: to identify metabolomics signatures able to discriminate the presence of ED by combining data provided by metabolomics analyses with those from PAT, and to correlate them with anthropometric, laboratory and genomic profiles of NAFLD subjects.
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