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Trientine tetrahydrochloride versus d-Penicillamine for the management of patients with Wilson Disease: results from the CHELATE trial a year after randomisation

      Introduction and Aims: Treatment of Wilson Disease (WD) with chelating agents such as d-Penicillamine (DPA) or trientine decreases the pathologic accumulation of copper and removes circulating non-ceruloplasmin bound copper (NCC). There are no prior controlled studies comparing DPA with trientine. The study aim is to determine if maintenance therapy for WD with a novel tetrahydrochloride trientine formulation (TETA4) is safe and effective when compared to DPA.
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