Abstract
Background
Studies to evaluate the use of mycophenolate mofetil (MMF) in inflammatory bowel disease
(IBD) are limited after the appearance of biological treatments.
Aims
Our primary objective was to evaluate the effectiveness and safety of MMF in IBD.
Methods
IBD patients who had received MMF were retrieved from the ENEIDA registry. Clinical
activity as per the Harvey‐Bradshaw Index (HBI), partial Mayo score (pMS), physician
global assessment (PGA) and C-reactive protein (CRP) were reviewed at baseline, at
3 and 6 months, and at final follow-up. Adverse events and causes of treatment discontinuation
were documented.
Results
A total of 83 patients were included (66 Crohn's disease, 17 ulcerative colitis),
90% of whom had previously received other immunosuppressants. In 61% of patients systemic
steroids were used at initiation of MMF, and in 27.3% biological agents were co-administered
with MMF. Overall clinical effectiveness was observed in 64.7% of the population.
At the end of treatment, 45.6% and 19.1% of subjects showed remission and clinical
response, respectively. MMF treatment was maintained for a median of 28.9 months (IQR:
20.4–37.5).
Conclusion
Our study suggests, in the largest cohort to date, that MMF may be an effective alternative
to thiopurines and methotrexate in IBD.
Keywords
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Article info
Publication history
Published online: November 30, 2021
Accepted:
October 7,
2021
Received:
May 11,
2021
Identification
Copyright
© 2021 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
