Objective
We have previously revealed the clinical factors and genetic polymorphisms associated
with gastrointestinal mucosal injury and bleeding, induced by low-dose aspirin (LDA).
After performing genome-wide analysis of single nucleotide polymorphisms (SNPs) using
the Drug Metabolizing Enzymes and Transporters (DMET) system among drug metabolism
and transporter genes, certain SNPs were found to increase the risk for LDA-induced
small bowel bleeding. The aim of this study was to identify the SNPs involved in LDA-induced
small bowel bleeding.
Subjects and methods
Subjects were patients taking LDA, with small bowel bleeding diagnosed using capsule
endoscopy. We investigated the clinical characteristics and the previously identified
SNPs, that were examined by the DNA direct sequence method.
Results
56 patients with bleeding and 410 controls taking LDA were enrolled. The risk factors
associated with small bowel bleeding included smoking, cerebrovascular diseases, chronic
renal failure, non-steroidal anti-inflammatory drug (NSAID) or anticoagulants combination,
and two SNPs (CYP4F11 20043G>A (D446N) rs1060463, GSTP1 313A>G rs1695). After propensity
score matching, GSTP1 rs1695 was significantly associated with small bowel bleeding.
Conclusion
The GSTP1 SNP may be a predictive marker for small bowel bleeding among patients taking
LDA.
Key words
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Article info
Publication history
Published online: May 28, 2021
Accepted:
April 30,
2021
Received:
March 8,
2021
Identification
Copyright
© 2021 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
