Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms
of the gastrointestinal (GI) tract. They originate from the interstitial cells of
Cajal and may develop anywhere along the GI tract [
[1]
,
[2]
, although accounting for only 0,1–3% of all GI neoplasms [
[3]
]. Involvement of regional and peripheral lymph nodes is unusual (1–2%) [
[1]
]. The coexistence of GIST with either synchronous or metachronous colorectal cancers
has been previously described only in few cases [
1
,
2
,
3
,
4
,
5
,
6
,
7
]. The question of whether such an occurrence is coincidental or results from related
pathophysiological processes should still be addressed. Here, we describe a patient
presenting synchronous jejunal GIST and rectal adenocarcinoma with GIST metastases
in perirectal lymph nodes and in the peritoneum. By next generation sequencing (NGS)
analysis of the samples, we detected common mutations, bona fide supporting the view of unique signaling pathway alterations.To read this article in full you will need to make a payment
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References
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Article info
Publication history
Published online: April 23, 2021
Accepted:
March 30,
2021
Received:
March 16,
2021
Identification
Copyright
© 2021 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
