Abstract
Background/Aim
H. pylori plays a major role in gastroduodenal diseases. Since its incidence is decreasing
in developed countries, gastric biopsies were negative in several patients managed
in clinical practice. We tested whether EndoFasterⓇ − a device allowing real-time H. pylori detection by gastric juice analysis – may optimize the need of biopsies.
Methods
In this prospective, multicentre study, the accuracy of EndoFasterⓇ for H. pylori detection was computed by using histology of gastric biopsies as a gold standard.
Results
Data of 525 consecutive patients were available, including 90 (17.1%) patients with
infection. Sensitivity, specificity, positive predictive value (PPV), negative predictive
value (NPV), and overall accuracy of EndoFasterⓇ were 87%, 84%, 53%, 97% and 85%, respectively. The overall accuracy of test was not
affected neither by ongoing proton pump inhibitor therapy nor by previous eradication
therapy. By using EndoFasterⓇ in our series, biopsy sampling could have been eventually avoided in a total of 279
patients, accounting for a reduction of 42.3%, accepting the risk of only 8 false
negative cases.
Conclusions
The very high NPV of EndoFasterⓇ might allow to safely halve the need of taking gastric biopsies in unselected patients
managed in clinical practice, avoiding an unavailing consume of health resources.
Keywords
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Article info
Publication history
Published online: March 03, 2021
Accepted:
February 1,
2021
Received:
January 19,
2021
Footnotes
Supports: No grant was received for this study.
Identification
Copyright
© 2021 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
