Abstract
Background
Cytomegalovirus (CMV) gastritis is occasionally reported in case reports and limited
case series. Up to now, it is the largest and most comprehensive retrospective study
of CMV gastritis.
Methods
All patients who were histologically diagnosed with CMV gastritis at Linkou Chang
Gung Memorial Hospital between January 2000 and April 2020 were included. Patients
were divided into two groups according to immunity. Between-group differences in characteristics,
manifestations, endoscopic features, prognostic factors, and outcomes were analyzed.
The main endpoint was 3-month mortality.
Results
A total of 54 patients (34 immunocompromised, 20 immunocompetent) were enrolled. Common
presentations included gastrointestinal bleeding (35.2%), abdominal pain (33.3%) and
fever (31.5%). The endoscopic features included ulcer (88.9%) and inflammation (11.1%).
The 3-month mortality rate was 20.4% and overall mortality rate was 40.7%. Acute kidney
injury was the only independent risk factor for 3-month mortality (OR 53.89, 95%CI
1.56–1861.73, p = 0.027). Anti-viral therapy and host immune status did not affect 3-month mortality.
Conclusion
Both immunocompromised and immunocompetent patients with CMV gastritis have high mortality
rates, without significant between-group differences. Acute kidney injury is the only
independent predictive factor for 3-month mortality. Prevention of acute kidney injury
may possibly improve the 3-month mortality rate.
Keywords
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Article info
Publication history
Published online: January 11, 2021
Accepted:
December 8,
2020
Received:
October 27,
2020
Identification
Copyright
© 2020 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
