Abstract
Background
Data regarding the effect of orthotopic liver transplantation (OLT) for primary sclerosing
cholangitis (PSC) on inflammatory bowel disease (IBD) course are scarce and conflicting.
Aims
To compare the incidence of refractory IBD in two groups (OLT and non-OLT) of patients
affected by IBD and PSC.
Methods
An observational, multicentre, cohort retrospective study was conducted by the Italian
Group for the study of IBD in Italy. The primary outcome was the need for biologic
therapy or bowel resection for medically refractory IBD or hospitalization due to
IBD relapse during the follow-up. Secondary outcomes were rate of colonic dysplasia,
colorectal cancer, other solid tumours, lymphoma.
Results
Eighty-four patients were included in the study. The primary outcome was not different
between OLT and non-OLT groups (11/27, 40.7%, versus 20/57, 35.1%, respectively, p = 0.62). The lymphoma and other tumours (thyroid cancer, kidney cancer, ileal tumour,
ovarian cancer, cervical cancer) rates were significantly higher in the OLT group
(p = 0.04 and p = 0.005, respectively), at the limit of statistical significance for high-grade colonic
dysplasia (p = 0.06).
Conclusion
OLT in patients affected by IBD and PSC is not a risk factor for a more severe IBD
course, but it is associated with a higher occurrence of cancer.
Keywords
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Article info
Publication history
Published online: September 21, 2020
Accepted:
September 15,
2020
Received:
June 24,
2020
Identification
Copyright
© 2020 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
