Abstract
Background/aim
Although inflammatory bowel disease (IBD) incidence has increased over the past two
decades in Asia, data on extraintestinal manifestations (EIMs) of IBD in Asian patients
are limited. We aimed to evaluate the prevalence and clinical characteristics of EIMs
in Asian IBD patients.
Methods
In total, 1,764 patients (1,130 with ulcerative colitis [UC] and 634 with Crohn's
disease [CD]) were recruited from 10 tertiary centers in Asia. The medical records
of IBD patients were retrospectively reviewed for the presence, clinical characteristics,
chronological order, and therapeutic management of EIMs.
Results
EIMs were reported in 199 (11.3%) patients, of which 17 (1.0%) patients had multiple
EIMs. EIMs were more prevalent in CD patients (P = 0.02). Multiple logistic regression analysis revealed that female sex (odds ratio
[OR] 2.02, 95% confidence interval [CI] 1.15–3.55), stricture (OR 2.49, 95% CI 1.41–4.39)
and female sex (OR 2.57, 95% CI 1.52–4.34), extensive colitis (OR 2.63, 95% CI 1.57–4.41)
were associated with EIMs in CD and UC patients respectively. EIMs appeared in 8%
of patients before IBD diagnosis; 95% of cases with EIM could be managed via first-line
therapy.
Conclusion
EIM prevalence is lower among Asian IBD patients than among patients from Western
countries; however, the risk factors for EIM were similar between both populations.
Keywords
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Article info
Publication history
Published online: July 29, 2020
Accepted:
June 29,
2020
Received in revised form:
June 29,
2020
Received:
May 26,
2020
Identification
Copyright
© 2020 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
