We were pleased to read the letter by Dr Patoulias, “Is there any place for sodium-glucose
co-transporter 2 inhibitors in post-liver transplantation patients?”, commenting our
study. We agree with the Authors on the possible beneficial effect of SGLT2-inhibitors
use for patients who underwent orthotropic liver transplantation (OLT), given the
absolute need for new therapeutic strategies able to prevent cardiac and atherosclerotic
damage.
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References
- The effects of Q1620 SGLT2 inhibitors on cardiovascular and renal outcomes in diabetic patients: a systematic review and meta-analysis.Cardiorenal Med. 2020; 10: 1-10
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Article info
Publication history
Published online: February 13, 2020
Received:
January 15,
2020
Identification
Copyright
© 2020 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
ScienceDirect
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- Is there any place for sodium-glucose co-transporter-2 inhibitors in post-liver transplantation patients?Digestive and Liver DiseaseVol. 52Issue 2
- Previewwe read with great interest the results of the prospective study conducted by Pisano and colleagues, concerning the early onset of atherosclerotic and cardiac damage after liver transplantation [1]. The researchers observed a significant increase in indices such as carotid intima-media thickness (cIMT), epicardial adipose tissue (EAT) and cardiac diastolic dysfunction, as assessed by the early diastolic (E-wave)/late diastolic (A-wave) ratio (E/A) and a non-significant increase in carotid-femoral pulse wave velocity (PWV), the established “gold-standard” of arterial stiffness, in a cohort of 50 patients that underwent liver transplantation [1].
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- High prevalence of early atherosclerotic and cardiac damage in patients undergoing liver transplantation: Preliminary resultsDigestive and Liver DiseaseVol. 52Issue 1
- PreviewLiver transplanted patients are at high risk of metabolic syndrome and its complications. We aimed to prospectively evaluate the early onset of cardiovascular alterations in patients submitted to the transplant waiting list. From January 2014 to January 2016, 54 out of 79 patients on the waiting list with decompensated cirrhosis or hepatocellular-carcinoma received the transplant, 50 were followed for 24 months, 2 died post-surgery and 2 were lost to follow-up. A significantly increased prevalence of visceral adiposity (epicardial adipose tissue thickness (p = 0.001) and worsening of carotid damage (p = 0.003) and diastolic dysfunction (E/A p = 0.001) was observed at 6 months after transplant and remained stable at 24 months, corresponding to an increased prevalence of diabetes, metabolic syndrome, hypertension and dyslipidemia.
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