Advertisement

Validation of Interleukin-32 as a new circulating fatty liver biomarker

  • Author Footnotes
    1 Equal Contributors.
    G.A. Baselli
    Footnotes
    1 Equal Contributors.
    Affiliations
    Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy

    Translational Medicine, Department of Transfusion Medicine and Hematology – Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
    Search for articles by this author
  • Author Footnotes
    1 Equal Contributors.
    P. Dongiovanni
    Footnotes
    1 Equal Contributors.
    Affiliations
    General Medicine and Metabolic Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
    Search for articles by this author
  • R. Rametta
    Affiliations
    General Medicine and Metabolic Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
    Search for articles by this author
  • M. Meroni
    Affiliations
    General Medicine and Metabolic Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
    Search for articles by this author
  • S. Pelusi
    Affiliations
    Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy

    Translational Medicine, Department of Transfusion Medicine and Hematology – Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
    Search for articles by this author
  • M. Maggioni
    Affiliations
    Pathology, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
    Search for articles by this author
  • S. Badiali
    Affiliations
    Surgery, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
    Search for articles by this author
  • P. Pingitore
    Affiliations
    Clinical Nutrition Unit, Department of Medical and Surgical Sciences, Magna Graecia University, Catanzaro, Italy
    Search for articles by this author
  • S. Maurotti
    Affiliations
    Clinical Nutrition Unit, Department of Medical and Surgical Sciences, Magna Graecia University, Catanzaro, Italy
    Search for articles by this author
  • T. Montalcini
    Affiliations
    Department of Clinical and Experimental Medicine, Nutrition Unit, University Magna Grecia, Catanzaro, Italy
    Search for articles by this author
  • A.E. Taliento
    Affiliations
    Translational Medicine, Department of Transfusion Medicine and Hematology – Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
    Search for articles by this author
  • D. Prati
    Affiliations
    Translational Medicine, Department of Transfusion Medicine and Hematology – Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
    Search for articles by this author
  • G. Rossi
    Affiliations
    Liver Transplantation Center, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
    Search for articles by this author
  • A.L. Fracanzani
    Affiliations
    Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy

    General Medicine and Metabolic Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
    Search for articles by this author
  • R.M. Mancina
    Affiliations
    Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden
    Search for articles by this author
  • S. Romeo
    Affiliations
    Clinical Nutrition Unit, Department of Medical and Surgical Sciences, Magna Graecia University, Catanzaro, Italy

    Sahlgrenska Center for Cardiovascular and Metabolic Research, Wallenberg Laboratory, Cardiology Department, University of Gothenburg, Gothenburg, Sweden
    Search for articles by this author
  • L.V.C. Valenti
    Affiliations
    Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy

    Translational Medicine, Department of Transfusion Medicine and Hematology – Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
    Search for articles by this author
  • Author Footnotes
    1 Equal Contributors.
      Introduction and Aims Efforts to manage nonalcoholic fatty liver disease (NAFLD) are limited by the absence of accurate noninvasive biomarkers. The I148 M variant in PNPLA3 is a major determinant of the development and progression of NAFLD associated with a distinct disease pathophysiology. Aim of the study was to identify novel candidate NAFLD biomarkers by examining the hepatic transcripts associated with severe NAFLD in obese individuals in patients stratified by the presence of the PNPLA3 I148 M variant.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Digestive and Liver Disease
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect