Abstract
Short bowel syndrome (SBS) is a rare malabsorptive disorder as a result of the loss
of bowel mass mostly secondary to surgical resection of the small intestine. Other
causes are vascular diseases, neoplasms or inflammatory bowel disease. The spectrum
of the disease is widely variable from single micronutrient malabsorption to complete
intestinal failure, depending on the remaining length of the small intestine, the
anatomical portion of intestine and the function of the remnant bowel. Over the last
years, the management of affected patients has remarkably improved with the increase
in patients’ quality of life and survival, mainly thanks to advances in home-based
parenteral nutrition (PN). In the last ten years new treatment strategies have become
available together with increasing experience and the encouraging results with new
drugs, such as teduglutide, have added a new dimension to the management of SBS.
This review aims to summarize the knowledge available in the current literature on
SBS epidemiology, pathophysiology, and its surgical (including intestinal lengthening
procedures and intestinal transplantation) and medical management with emphasis on
the recent advances.
Moreover, this review attempts to provide the new understanding and recent approaches
to SBS complications such as sepsis, catheter thrombosis, and intestinal failure-associated
liver disease.
Keywords
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Article info
Publication history
Published online: December 28, 2019
Accepted:
November 18,
2019
Received:
August 13,
2019
Identification
Copyright
© 2019 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
