Abstract
Introduction
Lumen apposing metal stents (LAMS) have been used increasingly for drainage of pancreatic
fluid collections (PFC). We present an international, multicenter study evaluating
the safety and efficacy of LAMS in PFCs.
Methods
Consecutive patients undergoing LAMS placement for PFC at 12 international centers
were included (ClinicalTrials.gov NCT01522573). Demographics, clinical history, and procedural details were recorded.
Technical success was defined as successful LAMS deployment. Clinical success was
defined as PFC resolution at three-month follow-up.
Results
192 patients were included (140 males (72.9%), mean-age 53.8 years), with mean follow-up
of 4.2 months ± 3.8. Mean PFC size was 11.9 cm (range 2–25). The median number of
endoscopic interventions was 2 (range 1–14). Etiologies for PFC were gallstone (n = 82,
42.7%), alcohol (n = 50, 26%), idiopathic (n = 26, 13.5%), and other (n = 34, 17.7%).
Technical success was achieved in 189 patients (98.4%). Clinical success was observed
in 125 of 135 patients (92.6%).
Adverse events included bleeding (n = 11, 5.7), infection (n = 2, 1%), and perforation
(n = 2, 1%). Three or more endoscopy sessions were a positive predictor for PFC resolution
and the only significant predictor for AEs.
Conclusion
LAMS has a high technical and clinical success rate with a low rate of AEs. PFC drainage
via LAMS provides a minimally invasive, safe, and efficacious procedure for PFC resolution.
Keywords
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Article info
Publication history
Published online: July 01, 2019
Accepted:
May 28,
2019
Received:
October 24,
2018
Identification
Copyright
© 2019 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
