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☆Portions of these discussed studies were supported by Baylor Scott & White Institute, the Hickam Endowed Chair, Gastroenterology, Medicine, Indiana University, a VA Research Senior Career Scientist Award.
☆☆The views expressed in this article are those of the authors and do not necessarily represent the views of the Department of Veterans Affairs.
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- The role of sphingosine kinase 2 in alcoholic liver diseaseDigestive and Liver DiseaseVol. 51Issue 8
- PreviewAlcoholic liver disease (ALD) is one of the most common liver diseases worldwide. However, the exact mechanisms underlying ALD remain unclear. Previous studies reported that sphingosine kinase 2 (SphK2) plays an essential role in regulating hepatic lipid metabolism. In the current study, we demonstrate that compared to wild-type (WT) mice, SphK2 deficient (SphK2−/−) mice exhibited a greater degree of liver injury and hepatic lipid accumulation after feeding with an alcohol diet for 60 days. This is accompanied by a down-regulation of steroid 7-alpha-hydroxylase (Cyp7b1) and an up-regulation of pro-inflammatory mediators (Tnfα, F4/80, Il-1β).