Abstract
Background
Children with autoimmune hepatitis (AIH) often exhibit particular features. Accordingly,
seven pediatric-specific criteria have been proposed.
Aim
To develop a prediction model based on them, transform it into a scoring system and
study its accuracy.
Methods
A cohort of children under study for liver disease was consecutively selected. AIH
diagnosis was based on classical criteria. Already proposed pediatric criteria were
recorded. The best possible regression model was selected, and the beta coefficient
of each criterion was translated into a whole number (points). Total scores were obtained
following the points system and the best cut-off was calculated. Subsequently, accuracy
of the diagnostic score was studied in the validation set.
Results
Among 212 included patients, 100 had AIH. The score included 5 criteria: autoantibodies
(0–2 points), hypergammaglobulinemia, exclusion of viral hepatitis, exclusion of Wilson’s
disease (1 point each) and liver histology (3 points). In addition, a normal cholangiogram
is mandatory. The validation set was formed of 70 patients (24 with AIH). In this
subsample, a score of ≥6 renders a sensitivity/specificity of 95.8%/100%. The area
under the receiver operating characteristic curve was 97.1%.
Conclusion
Pediatric-specific criteria for the diagnosis of AIH can be reliably used as a scoring
system.
Keywords
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Article info
Publication history
Published online: March 07, 2019
Accepted:
February 25,
2019
Received:
November 6,
2018
Identification
Copyright
© 2019 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
