Abstract
Background
Growing evidence supports that nonalcoholic fatty liver disease (NAFLD) is associated
with extrahepatic cancers. Nonalcoholic fatty liver disease (NAFLD) and breast cancer
share similar risk factors, including obesity.
Aim
The aim of this case-control study was to investigate the association between NAFLD
and breast cancer.
Methods
Subjects who received health screening, including mammography and breast and hepatic
ultrasonography simultaneously, were included. Subjects diagnosed with breast cancer
were matched with controls. Conditional logistic regression analyses were performed.
Results
Among 270 breast cancer patients and 270 controls, 81 cancer patients (30.0%) and
54 controls (20.0%) had NAFLD (P = 0.008). NAFLD was significantly associated with breast cancer in multivariate analysis
(P = 0.046). When the interaction between obesity (BMI < 25 kg/m2 vs. ≥25 kg/m2) and NAFLD in breast cancer patients was examined, a significant effect modification
between obesity and NAFLD in breast cancer was noted (P = 0.021). The subgroup analysis showed that NAFLD was significantly associated with
breast cancer in the nonobese subgroup (odds ratio 3.04, 95% confidence interval 1.37–4.32,
P = 0.002) but not in the obese group (P = 0.163).
Conclusions
NAFLD was significantly associated with breast cancer independent of traditional risk
factors, and this association existed in the nonobese subgroup but not in the obese
subgroup.
Keywords
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Article info
Publication history
Published online: January 09, 2019
Accepted:
December 24,
2018
Received:
September 21,
2018
Identification
Copyright
© 2019 Published by Elsevier Ltd on behalf of Editrice Gastroenterologica Italiana S.r.l.
