Abstract
Background
Data on erectile dysfunction (ED) in cirrhotic patients are limited as yet. Aim of
this study was to investigate the prevalence of ED and the factors potentially involved
in its development in compensated cirrhosis.
Methods
We prospectively enrolled 102 male (mean age 63 ± 10 years) affected by cirrhosis
in Child–Pugh Class A. The following questionnaires were used: simplified International
Index of Erectile Function (IIEF-5) Questionnaire, Centre of Epidemiologic Studies
Depression Scale and ANDROTEST.
Results
ED was found in 57/102(55.9%) patients, and was mild, moderate and severe in 21(36.8%),
6(10.5%) and 30(52.6%) subjects, respectively. ED patients were significantly older
than those without (66 ± 10 vs 60 ± 10,p = 0.006); ED prevalence gradually increased
with age. There was no statistically significant difference between patients with
and without ED concerning the coexistence of diabetes, hypertension, and cardiovascular
disease. Age(p = 0.040) and serum haemoglobin(p = 0.027) were identified as predictors
of ED on multivariate analysis. Liver-related factors and pharmacological treatment,
including β-blockers, were not associated with the presence of ED.
Conclusions
In patients with compensated liver cirrhosis, even in concomitance with other chronic
comorbidities, the prevalence of ED is not markedly different from the general population.
Compensated cirrhosis per se is not a risk factor for ED occurrence. Older age and
low haemoglobin values are significantly associated with ED in cirrhotics.
Keywords
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Article info
Publication history
Published online: October 29, 2018
Accepted:
October 18,
2018
Received:
August 7,
2018
Identification
Copyright
© 2018 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
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- Erectile dysfunction in patients with liver cirrhosisDigestive and Liver DiseaseVol. 51Issue 6
- PreviewErectile dysfunction (ED) is defined as the inability to achieve or maintain an erection sufficient for satisfactory sexual performance [1]. The reported prevalence of ED ranges between 10% and 50% in the general population and is related to age, overall health status and emotional function [2,3]. Based on this high prevalence of ED and the progressive importance given to health related quality of life (HRQoL) of the patients, several investigations into the clinical and pathophysiologic mechanisms of sexual dysfunction have been carried out during the last decade [4,5].
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