Abstract
Background
Adalimumab and golimumab are effective in the treatment of moderate to severe ulcerative
colitis.
Aims
We reported the comparative effectiveness of adalimumab and golimumab in ulcerative
colitis.
Methods
118 patients treated with adalimumab and 79 treated with golimumab were included and
evaluated at 8 weeks and at the end of follow up.
Results
Overall clinical benefit was 72.6% at 8 weeks and 58.9% at the end of follow up. Patients
with longer disease duration and those treated with adalimumab had a better outcome.
Clinical benefit was 78.8% in adalimumab patients and 63.3% in golimumab patients
(p = 0.026) after 8 weeks; it was 66.9% in adalimumab patients and 46.8% in golimumab
patients (p = 0.008) at the end of follow up. These data were confirmed by propensity
score analysis. A further analysis considering adalimumab optimization as treatment
failure showed that the difference between adalimumab and golimumab was not significant.
Conclusion
Adalimumab and golimumab are effective in the treatment of ulcerative colitis. Adalimumab
seems to be more effective than golimumab. This difference is probably affected by
the impossibility of golimumab to be optimized in Italy while adalimumab is.
Keywords
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Article info
Publication history
Published online: June 21, 2018
Accepted:
June 13,
2018
Received in revised form:
May 27,
2018
Received:
February 10,
2018
Identification
Copyright
© 2018 Published by Elsevier Ltd on behalf of Editrice Gastroenterologica Italiana S.r.l.
