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Metabolomics in the progression of non alcoholic fatty liver disease

  • J. Troisi
    Affiliations
    Internal Medicine and Hepatology Division, Department of Medicine and Surgery “Scuola Medica Salernitana”, University of Salerno, Salerno, Italy

    Theoreo srl – Spin-off company of the University of Salerno, Salerno, Italy
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  • M. Masarone
    Affiliations
    Internal Medicine and Hepatology Division, Department of Medicine and Surgery “Scuola Medica Salernitana”, University of Salerno, Salerno, Italy
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  • A. Aglitti
    Affiliations
    Internal Medicine and Hepatology Division, Department of Medicine and Surgery “Scuola Medica Salernitana”, University of Salerno, Salerno, Italy
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  • C. Di Zenzo
    Affiliations
    Internal Medicine and Hepatology Division, Department of Medicine and Surgery “Scuola Medica Salernitana”, University of Salerno, Salerno, Italy
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  • V. Rosato
    Affiliations
    Internal Medicine and Hepatology Division, Department of Medicine and Surgery “Scuola Medica Salernitana”, University of Salerno, Salerno, Italy
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  • M. Persico
    Affiliations
    Internal Medicine and Hepatology Division, Department of Medicine and Surgery “Scuola Medica Salernitana”, University of Salerno, Salerno, Italy
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      Introduction: Non-alcoholic-fatty-liver-disease (NAFLD) encompasses a wide spectrum of diseases that range from simple steatosis (NAFL) to steatosis with inflammation and fibrosis (namely non-alcoholic steatohepatits or NASH) up to cirrhosis and hepatocellular carcinoma (HCC). The greatest challenge in this field is to recognize the patient with a more severe and/or progressive pathology. A reliable noninvasive method based on biomarkers does not exist. Metabolomics is a novel and powerful method to discover biomarkers and gives insights on diseases pathophysiology. Few studies have applied this technique to NAFLD patients.
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