Abstract
Background
Mucosal healing (MH) has been proposed as an essential therapeutic goal for treatment
of Crohn’s disease (CD) patients. The utility of serum amyloid A (SAA) for prediction
of MH in CD patients is lacking.
Aims
This study was conducted to evaluate the correlation of SAA with CD-related endoscopic
disease activity.
Methods
SAA levels in serum samples obtained from CD patients as well as endoscopic findings
based on a simple endoscopic score for CD (SES-CD) were assessed in relation to CD
activity index (CDAI). The diagnostic ability of MH in correlation with SAA level
was evaluated using receiver operating characteristic (ROC) curve analysis.
Results
Fifty-five patients with CD were enrolled. Mean SAA level was significantly higher
in clinical and endoscopic active phases as compared to an inactive phase. SAA level
was also significantly correlated with SES-CD (r = 0.64, p < 0.01) and CDAI (r = 0.42,
p < 0.01). The area under the ROC curve for SAA level was 0.77 and the optimal cut-off
value for SAA to predict MH was 5.9 μg/dl. SAA level was shown to be associated with
MH, with a sensitivity of 68% and specificity of 83%.
Conclusions
SAA may be a possible biomarker for evaluating MH in CD patients.
Keywords
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Article info
Publication history
Published online: December 19, 2017
Accepted:
December 9,
2017
Received in revised form:
December 7,
2017
Received:
September 24,
2017
Identification
Copyright
© 2018 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
