Abstract
The technique of hepatic arterial infusion (HAI) for the treatment of liver metastases
from colorectal cancer has been developed over more than 30 years. Although the indications
and protocols for this technique have evolved with time, HAI is not routinely performed
in clinical practice. Studies have been heterogeneous, with different regimens of
intra-arterial drugs, associated or not with systemic chemotherapy, and with unconvincing
outcomes. Technical difficulties for catheter placement have limited the implementation
of this method in routine practice. The aim of this review is to present recent studies,
highlighting technical improvements and promising combinations of oxaliplatin-based
HAI with systemic treatments. HAI is being investigated in both the metastatic setting
– in the first line and beyond – and in the adjuvant setting, and we will discuss
its potential place in current and future patient management.
Keywords
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Article info
Publication history
Published online: December 14, 2017
Accepted:
December 6,
2017
Received in revised form:
December 4,
2017
Received:
August 12,
2017
Identification
Copyright
© 2017 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
