Abstract
Dramatic rises in hepatitis C virus (HCV) coinfection rates in human immunodeficiency
virus (HIV)-infected individuals have been observed recently, largely attributable
to increasing recreational drug use combined with increased testing for HCV. In the
era of direct-acting antiviral (DAA) therapy, treatment of acute HCV infection in
HIV-infected individuals with short durations of these drugs may potentially reduce
the disease and economic burden associated with HCV infection as well as reducing
the likelihood of onward HCV transmission. We performed an extensive literature search
of PubMed, Embase and Google Scholar up to 05 September 2017 for clinical trials of
acute HCV infection in HIV-infected individuals. In the studies identified, rates
of sustained virologic response at 12 weeks post-treatment (SVR12) ranged from 21%
with 6 weeks of therapy up to 92% with 12 weeks of therapy with sofosbuvir and ribavirin.
Ledipasvir/sofosbuvir for 6 weeks achieved an SVR of 77%. No HIV-related events occurred
regardless of whether patients were receiving antiretroviral therapy (ART) and DAAs
were well tolerated. Data is currently limited with regards to optimal regimens and
durations of therapy, which need to be tailored based on potential interactions with
concurrent ART and consideration for the fact that patients with higher baseline HCV
RNA levels may require an extended duration of treatment.
Keywords
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Article info
Publication history
Published online: November 27, 2017
Accepted:
November 15,
2017
Received in revised form:
October 29,
2017
Received:
October 5,
2017
Identification
Copyright
© 2017 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
