Abstract
Background
It has been suggested that acute histological activity has a prognostic value in the
outcome of ulcerative colitis (UC) patients in clinical and endoscopic remission.
Our aim was to assess the role of histology as a risk factor for clinical relapse
(CR) in patients in both clinical and endoscopic remission.
Methods
Patients with left-sided or extensive UC in clinical and endoscopic remission (Mayo
endoscopic subscore ≤1) undergoing colonoscopy for dysplasia surveillance with random
colonic biopsies between 2005–2015 were included. Basal plasmacytosis, acute (AHA),
and the chronic (CHA) histological inflammatory activity of all biopsy sets were evaluated.
Results
One hundred and thirteen patients were included. Median time in clinical remission
at inclusion was 27 months (IQR 15–56). Eight percent of patients relapsed within
the first year and 33% during the whole follow-up period. In the univariate analysis,
the presence of AHA, alone (P = 0.048) or together with a past flare within the previous 12 months (P = 0.01), was associated with CR within the first year of follow-up. In the multivariate
analysis, AHA, together with a flare within the previous 12 months, remained the only
risk factor for relapse (RR = 7.5; IC95%; 1.8–29.9; P = 0.005).
Conclusions
In UC patients in clinical and endoscopic remission, the presence of AHA is a risk
factor for clinical relapse.
Keywords
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Article info
Publication history
Published online: September 08, 2017
Accepted:
August 27,
2017
Received in revised form:
August 22,
2017
Received:
July 2,
2017
Identification
Copyright
© 2017 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
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