Abstract
Background
Risk of pancreatic cancer may increase in chronic pancreatitis patients.
Aims
This study aimed to identify the incidence of and risk factors for pancreatic cancer
in chronic pancreatitis patients.
Methods
Chronic pancreatitis patients admitted to our center from January 2000 to December
2013 were enrolled. Cumulative rates of pancreatic cancer and survival rates were
calculated. The standardized incidence ratio was calculated based on the pancreatic
cancer incidence in general population of China. Risk factors for pancreatic cancer
were identified.
Results
In a total of 1656 patients, the median follow-up duration was 8.0 years. Pancreatic
cancer was detected in 21 patients (1.3%). The expected number of cases of pancreatic
cancer was 1.039, yielding a standardized incidence ratio of 20.22. The standardized
incidence ratios for patients with a >60 pack-year smoking history were much higher
(145.82). Two risk factors for pancreatic cancer were identified: age at the onset
of chronic pancreatitis (hazard ratio, 1.05) and a >60 pack-year smoking history (hazard
ratio, 11.83).
Conclusion
The risk of pancreatic cancer is markedly increased in chronic pancreatitis patients
compared with the general population, especially in patients with an older age at
onset and a >60 pack-year smoking history. The high-risk populations were suggested
to be followed up closely.
Keywords
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Article info
Publication history
Published online: July 14, 2017
Accepted:
July 7,
2017
Received in revised form:
July 5,
2017
Received:
February 25,
2017
Identification
Copyright
© 2017 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
