Abstract
Background
Many studies have reported significant changes in intestinal microbiota in irritable
bowel syndrome (IBS) patients based on quantitative real-time PCR analysis.
Aims
We aimed to review the alterations in intestinal microbiota.
Methods
An online search up to June 9, 2016, was conducted. This systematic review and meta-analysis
included differential expression of intestinal microbiota in patients with IBS versus
healthy controls (HCs) and subgroup analysis. We assessed the quality of the included
studies using an original assessment tool.
Results
A total of 13 articles involving 360 IBS patients and 268 healthy controls were included.
The quality assessment scores for these articles ranged from 5 to 8. Significant differences
in expression in IBS patients were observed for Lactobacillus (SMD = −0.85, P < 0.001, I2 = 28%), Bifidobacterium (SMD = −1.17, P < 0.001, I2 = 79.3%), and Faecalibacterium prausnitzii (SMD = −1.05, P < 0.001, I2 = 0.0%) but not Bacteroides-Prevotella group, Escherichia coli or other genera or species. Subgroup analysis showed that diarrhea-predominant IBS
patients had significantly different expression of Lactobacillus (SMD = −1.81, P < 0.001) and Bifidobacterium (SMD = −1.45, P < 0.001).
Conclusion
Down-regulation of bacterial colonization including Lactobacillus, Bifidobacterium and F. prausnitzii was observed in IBS patients, particularly in diarrhea-predominant IBS (IBS-D). Microbiota
changes participate in the pathogenesis of IBS and may underlie the efficacy of probiotic
supplements.
Keywords
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Article info
Publication history
Published online: January 21, 2017
Accepted:
January 9,
2017
Received:
June 19,
2016
Identification
Copyright
© 2017 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.