Abstract
Inflammatory bowel diseases are chronic conditions of unknown etiology, showing a
growing incidence and prevalence in several countries, including Italy. Although the
etiology of Crohn’s disease and ulcerative colitis is unknown, due to the current
knowledge regarding their pathogenesis, effective treatment strategies have been developed. Several guidelines
are available regarding the efficacy and safety of available drug treatments for inflammatory
bowel diseases. Nevertheless, national guidelines provide additional information adapted
to local feasibility, costs and legal issues related to the use of the same drugs.
These observations prompted the Italian Group for the Study of Inflammatory Bowel
Disease (IG-IBD) to establish Italian guidelines on the safety of currently available
treatments for Crohn’s disease and ulcerative colitis. These guidelines discuss the
use of aminosalicylates, systemic and low bioavailability corticosteroids, antibiotics
(metronidazole, ciprofloxacin, rifaximin), thiopurines, methotrexate, cyclosporine
A, TNFα antagonists, vedolizumab, and combination therapies. These guidelines are
based on current knowledge derived from evidence-based medicine coupled with clinical
experience of a national working group.
Keywords
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