Abstract
Background
Altered body composition is frequently observed in Crohn’s disease (CD) patients.
Aims
To investigate the nutritional status, and the effect of different therapeutic regimes
in adult CD patients.
Methods
Fat free mass (FFM) and BIA-derived phase angle (PhA) were assessed in 45 CD patients,
22 on conventional therapy (CT) and 23 on maintenance therapy with infliximab (MT).
Nutritional status was also assessed in 12 CD patients before and following the induction
protocol with infliximab. BIA data of CD patients were compared with those of 20 healthy
asymptomatic volunteers. In CD patients C Reactive Protein (CRP) and albuminaemia
dosage were obtained.
Results
The mean values of PhA and of FFM were significantly lower in CT patients when compared
with control group and MT patients. Following infliximab treatment FFM increased,
although not significantly, while mean phase angle value significantly increased from
4.6 ± 0.3 to 6.2 ± 0.4 (p < 0.05). CRP was significantly lower in MT patients compared to that in CT patients.
Conclusion
CD patients on conventional therapy showed a lower FFM and a lower mean phase angle
score compared to those on infliximab therapy. Following infliximab treatment the
mean phase angle score normalized. PhA is a reliable nutritional indicator in IBD
patients and could be considered as an additional tool for assessing response to treatment.
Keywords
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Article Info
Publication History
Published online: December 31, 2016
Accepted:
December 22,
2016
Received in revised form:
December 16,
2016
Received:
August 19,
2016
Identification
Copyright
© 2016 Published by Elsevier Ltd on behalf of Editrice Gastroenterologica Italiana S.r.l.
