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Gut microbiota composition and products contribute to gut–liver axis dysfunction in pediatric obesity related NAFLD, with distinct metabolomic signature

  • S. Guercio Nuzio
    Correspondence
    Corresponding author.
    Affiliations
    Pediatrics, Dep. of Medicine and Surgery, University of Salerno, Baronissi (Sa), Italy

    University Hospital “San Giovanni di Dio e Ruggi d’Aragona”, Salerno, Italy
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  • L. Pierri
    Affiliations
    Pediatrics, Dep. of Medicine and Surgery, University of Salerno, Baronissi (Sa), Italy

    University Hospital “San Giovanni di Dio e Ruggi d’Aragona”, Salerno, Italy
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  • J. Troisi
    Affiliations
    Lab. of Metabolomics Theoreo, Salerno, Italy

    University Hospital “San Giovanni di Dio e Ruggi d’Aragona”, Salerno, Italy
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  • P. Saggese
    Affiliations
    Lab. of Molecular Medicine and Genomics, Dep. of Medicine and Surgery, University of Salerno, Baronissi (SA), Italy

    University Hospital “San Giovanni di Dio e Ruggi d’Aragona”, Salerno, Italy
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  • M. Poeta
    Affiliations
    Pediatrics, Dep. of Medicine and Surgery, University of Salerno, Baronissi (Sa), Italy

    University Hospital “San Giovanni di Dio e Ruggi d’Aragona”, Salerno, Italy
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  • M. Di Stasi
    Affiliations
    Pediatrics, Dep. of Medicine and Surgery, University of Salerno, Baronissi (Sa), Italy

    University Hospital “San Giovanni di Dio e Ruggi d’Aragona”, Salerno, Italy
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  • A. Landolfi
    Affiliations
    Lab. of Metabolomics Theoreo, Salerno, Italy

    University Hospital “San Giovanni di Dio e Ruggi d’Aragona”, Salerno, Italy
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  • F. Marciano
    Affiliations
    Pediatrics, Dep. of Medicine and Surgery, University of Salerno, Baronissi (Sa), Italy

    University Hospital “San Giovanni di Dio e Ruggi d’Aragona”, Salerno, Italy
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  • A. Bisogno
    Affiliations
    Pediatrics, Dep. of Medicine and Surgery, University of Salerno, Baronissi (Sa), Italy

    University Hospital “San Giovanni di Dio e Ruggi d’Aragona”, Salerno, Italy
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  • F. Belmonte
    Affiliations
    Pediatrics, Dep. of Medicine and Surgery, University of Salerno, Baronissi (Sa), Italy

    University Hospital “San Giovanni di Dio e Ruggi d’Aragona”, Salerno, Italy
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  • C. Palladino
    Affiliations
    Pediatrics, Dep. of Medicine and Surgery, University of Salerno, Baronissi (Sa), Italy

    University Hospital “San Giovanni di Dio e Ruggi d’Aragona”, Salerno, Italy
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  • M. Tripodi
    Affiliations
    Pediatrics, Dep. of Medicine and Surgery, University of Salerno, Baronissi (Sa), Italy

    University Hospital “San Giovanni di Dio e Ruggi d’Aragona”, Salerno, Italy
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  • A. Weisz
    Affiliations
    Lab. of Molecular Medicine and Genomics, Dep. of Medicine and Surgery, University of Salerno, Baronissi (SA), Italy

    University Hospital “San Giovanni di Dio e Ruggi d’Aragona”, Salerno, Italy
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  • P. Vajro
    Affiliations
    Pediatrics, Dep. of Medicine and Surgery, University of Salerno, Baronissi (Sa), Italy

    University Hospital “San Giovanni di Dio e Ruggi d’Aragona”, Salerno, Italy
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      Gut microbiota (GM) and intestinal permeability (IP) are reported to interplay with wrong lifestyle in determining pediatric obesity (PO)/obesity-related complications. We concurrently investigated GM and gut-liver axis (GLA) components in 26 pre-pubertal obese children [OB(+)] with/without hepatic steatosis (13[ST(+)]/13[ST(−)]), vs 14 normal weight (NW) controls.
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