Barrett's esophagus (BE), defined as the replacement of physiological squamous epithelium
of the lower esophagus by metaplastic columnar epithelium containing goblet cells,
is a premalignant condition that can lead to esophageal adenocarcinoma through dysplasia
with an annual risk of about 0.5% [
1
,
2
,
3
]. The major determinant of BE is represented by gastro-esophageal reflux, which promotes
chronic inflammation and progressively induces the metaplastic transformation in predisposed
subjects [
4
,
5
]. Indeed, several pathophysiological studies carried out with the state-of-the-art
technology clearly demonstrated that the severity of BE directly correlates with esophageal
acid exposure and reflux occurrence of any type [
6
,
7
]. Further, BE and GERD share multiple common risk factors, including obesity and smoke
[
8
,
9
].To read this article in full you will need to make a payment
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Article info
Publication history
Published online: June 26, 2016
Identification
Copyright
© 2016 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
