Abstract
Background
Treatment of ulcerative colitis (UC) is aimed at maintaining corticosteroid-free remission
and improving quality of life (QoL).
Aim
Assess patients’ perception of disease burden and unmet clinical needs in moderate/severe
UC patients.
Methods
Adults surgery-free conventionally treated patients with Mayo score ≥6 were enrolled
in an observational, cross-sectional, retrospective study in 11 European countries.
Disease control was defined as Mayo score ≤2 with no sub-score >1. No corticosteroid
was used the previous two months. Unmet clinical needs were defined as: non-controlled
disease, self-perception of ‘moderate’/‘severe’ disease, and dissatisfaction with
treatments. Disease burden on QoL and work productivity were assessed (EuroQol-5D-5L,
Short Inflammatory Bowel Disease Questionnaire (SIBDQ) and Work Productivity and Activity
Impairment (WPAI) in UC questionnaire).
Results
UC patients (n = 253) with mean Mayo score at enrolment of 4.9, 44.3% of patients had Mayo score ≥6.
Main treatment was 5-ASA (75%). Overall, 25% met the composite endpoint for unmet
clinical needs.
Mean (SD) questionnaire scores were: EQ-5D-5L-VAS, 71 (19.1), EQ-5D-5L utility, 0.77
(0.19), SIBDQ, 4.8 (1.3), and WPAI, 26% (32%).
Conclusions
Patients with moderate/severe UC in the last 12 months treated with conventional therapies
felt that their disease was not controlled and 25% reported unmet clinical needs.
QoL and work productivity were seriously impaired.
Keywords
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Article info
Publication history
Published online: February 26, 2016
Accepted:
January 18,
2016
Received:
September 30,
2015
Identification
Copyright
© 2016 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
