Abstract
Background
Anaemia (AN) is frequently associated with inflammatory bowel diseases (IBD) and can
negatively influence the quality of life of patients.
Aim
To evaluate the prevalence and causes of AN in IBD.
Methods
We prospectively performed a one-year multicentre observational study including all
IBD cases attending six Units. We also investigated patients’ main serological parameters.
Results
The study population included 965 IBD patients (582 CD; 383 UC), of whom 142 were
in-patients and 823 out-patients. AN was diagnosed in 134 out of 965 IBD patients
(14%). No significant difference in AN prevalence was observed between CD and UC.
The prevalence of AN was higher in the hospitalized IBD (26% in- vs. 11.7% out-patients;
p < 0.01; OR 2.2) and in active disease (CD: 34% active vs. 16% inactive; p < 0.01; OR 2.1 – UC: 26% active vs. 19% inactive; p = 0.03; OR 1.3). Iron deficiency was present in 72 patients (53.7%), AN of chronic diseases
in 12 (8.2%), mixed type AN in 11 (8.2%), thalassemia in 9 (6.7%), and macrocytic
AN in 8 (5.9%).
Conclusions
In Southern Italy, AN is common in IBD and is more frequent in active disease and
hospitalized patients. Iron deficiency still remains the major cause of AN in IBD.
Keywords
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Article info
Publication history
Published online: December 14, 2015
Accepted:
October 13,
2015
Received:
August 24,
2015
Identification
Copyright
© 2015 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Inc. All rights reserved.
